What is metformin ?
Metformin is the name of an active ingredient which is commonly used to treat the symptoms of diabetes, metformin was derived from an old substance extracted from ( Galega Officinalis ), this herb is called also the French lilac or Italian Fitch The original ingredient which was extracted from Galega Officinalis had many toxic effects when used for chronic treatments. In the 20th Century the metformin was developed and provided a high safety margin for the diabetes mellitus treatment nowadays exact mode of action of the metformin still unclear, but metformin products are widely used in almost all drug pharmacopeias all over the world.
What are Trade names of metformin in United States ?
Metformin is sold under several trade names, including Glucophage XR, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, and Diaformin.
Metformin IR (immediate release) is available in 500 mg, 850 mg, and 1000 mg tablets, all now generic in the US.
Metformin SR (slow release) or XR (extended release) was introduced in 2004, in 500 mg and 750 mg strengths, mainly to counteract the most common gastrointestinal side-effects, as well as to increase patient compliance by reducing pill burden. No difference in effectiveness exists between the two preparations.
What is Metformin Weight Loss ?
Metformin is the name of an active ingredient which is commonly used to treat the symptoms of diabetes, metformin was derived from an old substance extracted from ( Galega Officinalis ), this herb is called also the French lilac or Italian Fitch The original ingredient which was extracted from Galega Officinalis had many toxic effects when used for chronic treatments.
In the 20th Century the metformin was developed and provided a high safety margin for the diabetes mellitus treatment nowadays. The exact mode of action of the metformin still unclear, but metformin products are widely used in almost all drug pharmacopeias all over the world.
History of usage of Metformin in Weight Loss.
Patients of Type 2 diabetes mellitus which used metformin prescriptions, found that this drug had an adverse effect of losing weight, This information was exploited by some physicians to try the metformin to treat their obese patients either men or women.
In the last two decades, many obese people used Glucophage ( metformin) as
anti-obesity drug, reporting good results for 74 % of them, put also a various side effects appeared, the main side effect of using metformin for a non-diabetic person was the unexpected low glucose blood levels, causing Tiredness, dizziness, and in rare cases Coma.
How does the metformin work in weight loss ?
It is known that metformin helps to lose weight by different mechanisms, these effects in total cause to reduce the hunger sensation, because the metformin drug can reduce the blood glucose level, and also it increases the tissues insulin sensitivity to utilize the glucose into energy in your body. Although that we don't know how exactly metformin works in weight loss aid, but the history of thousands of people who was used metformin says that the metformin effect on weight loss is true, despite some controllable side effects
What are Brand names ( Trade names ) of Metformin ?
Metformin is a famous widely used drug, so it has a lot of trade names in various markets in the world. These are some known Trade names of Metformin : Glucophage XR, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, and Diaformin.
Metformin is available in 500 mg, 850 mg , and 1000 mg Tablets. In other markets a tablet of 750 mg Sustained Release is also available.
Other great effects of metformin in breast cancer treatments
Metfromin, also known as Glucophage as a trade name, this amazing drug that becomes the most widely used drug in the control of Diabetes Type 2 . It seems that metformin will also have another important role to reduce the suffer of millions of people, in addition to the diabetes, PCOS, weight loss aid, The metformin is nominated to prevent certain types of cancer, or at least to control the further development of the tumor.
After noting the increase in the potential risk of cancer in obese women with diabetes, the attention turned to the possibility of a link between the state of diabetic patients and treatments used to control the glucose level, and between reducing the risk of cancer, and on the light of this idea a recent study has been planned for a limited number of women in a health center in Germany where the proportion of 12% of them have diabetes for more than a year and use the insulin injections for diabetes control, while 36% of them are also diabetic and use the drug Glucophage (metformin), and only 3% of them have a history of breast cancer and have treated by conduction operations for the breast cancer tumor, but they are not diabetic, while 49% suffer from obesity and have no history of breast cancer or diabetes, at the beginning of the research, the focus won't on the potential role of metformin in reducing the risk of cancer occurrence but the main objective of the study was attempt to gain the access to the relationship between diabetes and increased risk of breast cancer in particular, Then after 3 months, it was observed that there was an almost certain to the elevation of the risk of cancer, in obese women, over those who enjoy a healthy normal body weights. It was also observed that the risk is near the double in obese women which suffer from diabetes mellitus type II, and therefore the main attention was turned to the role of the drugs used in the treatment of type II diabetes in reducing this risk of breast cancer.
After reviewing the results of the tests , the amazing discovery was appeared, And it was that , women who are using the drug metformin for the treatment of diabetes, are much less vulnerable to the risk of cancers, especially breast cancer, and that changed the course of the study completely, but unfortunately the study was limited to a small number of women, and was not enough to aver the relationship between cancer and metformin, but it gave a new hope for these doctors to discover a new by-chance way to resist this disease, which affected more that 8 % of the world's women over the age of 40, and it also gave the hope to millions of women even a little chance of the disposal of this treacherous killer.